Clinical ophthalmology (Auckland, N.Z.) · 2020
The Effect of Brimonidine 0.1% on Disc Hemorrhage in Primary Open-Angle Glaucoma Patients.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nitta Koji, Shimamoto Shiro, Wajima Ryotaro, Tachibana Gaku, Yamada Yutaro, Domoto Miyuki, Takeda Ryuji, Takahashi Yoshinari, Sugiyama Kazuhisa
Аннотация
BACKGROUND: This retrospective study evaluated the effect of adjunctive administration of brimonidine 0.1% on disc hemorrhage (DH) in patients with primary open-angle glaucoma or normal-tension glaucoma who were already treated with other anti-glaucoma drugs.
METHODS: Patients with DH, before adjunctive therapy with brimonidine, were enrolled. Subjects were excluded if their treatment regimen was changed within 1 year after initiation of adjunctive therapy with brimonidine. We investigated the frequency of DH and intraocular pressure (IOP). Both parameters were compared before and after adjunctive administration of brimonidine.
RESULTS: The frequency of DH before and after brimonidine administration was 0.67±0.68 and 0.31±0.72 times/year, respectively, with a significant decrease (P=0.01), and the mean IOP before and after brimonidine administration was 12.5±1.9 and 11.2±2.2 mmHg, respectively, (P=0.0006) with a significant reduction after adjunctive administration.
CONCLUSION: The results of this study supported the hypothesis that the frequency of DH is reduced by brimonidine alongside lowering of IOP.
METHODS: Patients with DH, before adjunctive therapy with brimonidine, were enrolled. Subjects were excluded if their treatment regimen was changed within 1 year after initiation of adjunctive therapy with brimonidine. We investigated the frequency of DH and intraocular pressure (IOP). Both parameters were compared before and after adjunctive administration of brimonidine.
RESULTS: The frequency of DH before and after brimonidine administration was 0.67±0.68 and 0.31±0.72 times/year, respectively, with a significant decrease (P=0.01), and the mean IOP before and after brimonidine administration was 12.5±1.9 and 11.2±2.2 mmHg, respectively, (P=0.0006) with a significant reduction after adjunctive administration.
CONCLUSION: The results of this study supported the hypothesis that the frequency of DH is reduced by brimonidine alongside lowering of IOP.