Accumulation of 3H-estradiol in the vaginas and pituitary glands of mice of inbred strains.

The sensitivity of the vaginal epithelium of ovariectomized mice of the A and C57 strains to estradiol differ approximately fivefold. The vaginas of the more sensitive C57 strain did accumulate more 333H-E2 at 1 hr in two or three experiments but the retention at 6 and 12 hr was not significantly different. The pituitary accumulation of H-E2 by the pituitary-tumor susceptable C57 mice, although not significantly greater than that of the nonsusceptable A strain mice at 1 hr was higher at 6 and 12 hr after the injection. Most of the toluene extractable radioactivity from pituitary glands and vaginas was estradiol with no strain differences. The accumulation of H-E2 in other tissues was not significantly different in mice of the two strains.