Journal of the National Comprehensive Cancer Network : JNCCN · 2020
Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology.
СтатьяКлинические рекомендацииНазвание и аннотация: Перевод пока не подготовлен
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Gerds Aaron T, Gotlib Jason, Bose Prithviraj, Deininger Michael W, Dunbar Andrew, Elshoury Amro, George Tracy I, Gojo Ivana, Gundabolu Krishna, Hexner Elizabeth, Hobbs Gabriela, Jain Tania, Jamieson Catriona, Kuykendall Andrew T, McMahon Brandon, Mohan Sanjay R, Oehler Vivian, Oh Stephen, Pardanani Animesh, Podoltsev Nikolai, Ranheim Erik, Rein Lindsay, Salit Rachel, Snyder David S, Stein Brady L, Talpaz Moshe, Thota Swapna, Vachhani Pankit, Wadleigh Martha, Walsh Katherine, Ward Dawn C, Bergman Mary Anne, Sundar Hema
Аннотация
Eosinophilic disorders and related syndromes represent a heterogeneous group of neoplastic and nonneoplastic conditions, characterized by more eosinophils in the peripheral blood, and may involve eosinophil-induced organ damage. In the WHO classification of myeloid and lymphoid neoplasms, eosinophilic disorders characterized by dysregulated tyrosine kinase (TK) fusion genes are recognized as a new category termed, myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB or FGFR1 or with PCM1-JAK2. In addition to these aforementioned TK fusion genes, rearrangements involving FLT3 and ABL1 genes have also been described. These new NCCN Guidelines include recommendations for the diagnosis, staging, and treatment of any one of the myeloid/lymphoid neoplasms with eosinophilia (MLN-Eo) and a TK fusion gene included in the 2017 WHO Classification, as well as MLN-Eo and a FLT3 or ABL1 rearrangement.