Gastrointestinal endoscopy · 2015
Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial.
Сравнительное исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Rex Douglas K, Clodfelter Ryan, Rahmani Farrah, Fatima Hala, James-Stevenson Toyia N, Tang John C, Kim Hak Nam, McHenry Lee, Kahi Charles J, Rogers Nicholas A, Helper Debra J, Sagi Sashidhar V, Kessler William R, Wo John M, Fischer Monika, Kwo Paul Y
Аннотация
BACKGROUND: The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown.
OBJECTIVE: To assess NBI for the detection of proximal colon serrated lesions.
DESIGN: Randomized, controlled trial.
SETTING: Two academic hospital outpatient units.
PATIENTS: Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations.
INTERVENTIONS: Randomization to colon inspection in NBI versus white-light colonoscopy.
MAIN OUTCOME MEASUREMENTS: The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon.
RESULTS: The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups.
LIMITATIONS: Lack of blinding, endoscopic estimation of polyp location.
CONCLUSION: NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (
CLINICAL TRIAL REGISTRATION NUMBER: NCT01572428.).
OBJECTIVE: To assess NBI for the detection of proximal colon serrated lesions.
DESIGN: Randomized, controlled trial.
SETTING: Two academic hospital outpatient units.
PATIENTS: Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations.
INTERVENTIONS: Randomization to colon inspection in NBI versus white-light colonoscopy.
MAIN OUTCOME MEASUREMENTS: The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon.
RESULTS: The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups.
LIMITATIONS: Lack of blinding, endoscopic estimation of polyp location.
CONCLUSION: NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (
CLINICAL TRIAL REGISTRATION NUMBER: NCT01572428.).