Circulating inflammatory biomarkers, adipokines and breast cancer risk-a case-control study nested within the EPIC cohort.
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Cairat Manon, Rinaldi Sabina, Navionis Anne-Sophie, Romieu Isabelle, Biessy Carine, Viallon Vivian, Olsen Anja, Tjønneland Anne, Fournier Agnès, Severi Gianluca, Kvaskoff Marina, Fortner Renée T, Kaaks Rudolf, Aleksandrova Krasimira, Schulze Matthias B, Masala Giovanna, Tumino Rosario, Sieri Sabina, Grasso Chiara, Mattiello Amalia, Gram Inger T, Olsen Karina Standahl, Agudo Antonio, Etxezarreta Pilar Amiano, Sánchez Maria-Jose, Santiuste Carmen, Barricarte Aurelio, Monninkhof Evelyn, Hiensch Anouk E, Muller David, Merritt Melissa A, Travis Ruth C, Weiderpass Elisabete, Gunter Marc J, Dossus Laure
Аннотация
METHODS: Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We used conditional logistic regression to estimate the odds ratios (ORs) of breast cancer at blood collection, per one standard deviation increase in biomarker concentration.
RESULTS: Cases were diagnosed at a mean age of 61.4 years on average 8.6 years after blood collection. No statistically significant association was observed between inflammatory markers and breast cancer risk overall. In premenopausal women, borderline significant inverse associations were observed for leptin, leptin-to-adiponectin ratio and CRP [OR= 0.89 (0.77-1.03), OR= 0.88 (0.76-1.01) and OR= 0.87 (0.75-1.01), respectively] while positive associations were observed among postmenopausal women [OR= 1.16 (1.05-1.29), OR= 1.11 (1.01-1.23), OR= 1.10 (0.99-1.22), respectively]. Adjustment for BMI strengthened the estimates in premenopausal women [leptin: OR = 0.83 (0.68-1.00), leptin-to-adiponectin ratio: OR = 0.80 (0.66-0.97), CRP: OR = 0.85 (0.72-1.00)] but attenuated the estimates in postmenopausal women [leptin: OR = 1.09 (0.96-1.24), leptin-to-adiponectin ratio: OR = 1.02 (0.89-1.16), CRP: OR = 1.04 (0.92-1.16)].
CONCLUSIONS: Associations between CRP, leptin and leptin-to-adiponectin ratio with breast cancer risk may represent the dual effect of obesity by menopausal status although this deserves further investigation.