Investigative ophthalmology & visual science · 2026
Detailed Outer Retinal Assessment in Parkinson's Disease Using Directional OCT.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lin Jingjing, Lee Pei Ying, Tran Katie K N, Finkelstein David I, Bui Bang V, Nguyen Christine T O
Аннотация
PURPOSE: This study aimed to compare outer retinal thickness and reflectivity using directional OCT between people living with Parkinson's disease (PD) and age-matched controls.
METHODS: Fourteen neurologist-confirmed people living with PD and 18 age-matched healthy controls participated. To measure the true outer nuclear layer (ONL) (composed of photoreceptor cell bodies) rather than the conventional presumed or standard ONL (ONL plus Henle fiber layer [HFL], which includes photoreceptor processes), off-axis (directional) OCT scans were acquired by altering the incident beam angle. Combined with on-axis (standard) line scans to yield HFL, true ONL and HFL thicknesses as well as ellipsoid zone (EZ) reflectivity were measured and compared between groups using a mixed-effects analysis.
RESULTS: Directional OCT revealed that true ONL comprises 63% of the presumed ONL thickness. Compared with healthy controls, the PD group showed a thicker true ONL and a thinner HFL (P < 0.05), whereas the combined ONL and HFL thickness was not different (P > 0.05). The EZ band exhibited lower reflectance in PD participants than healthy controls at the fovea and parafoveal regions (P < 0.05).
CONCLUSIONS: Directional OCT reveals that people with PD have a thicker photoreceptor nuclear layer and a thinner layer of photoreceptor processes. These opposing effects are not detectable using standard on-axis OCT alone. The EZ band is rich in mitochondria, and a lower reflectivity in PD participants may be indicative of metabolic changes in PD. These detailed examinations of the outer retina facilitate a deeper understanding of PD-related photoreceptor changes.
METHODS: Fourteen neurologist-confirmed people living with PD and 18 age-matched healthy controls participated. To measure the true outer nuclear layer (ONL) (composed of photoreceptor cell bodies) rather than the conventional presumed or standard ONL (ONL plus Henle fiber layer [HFL], which includes photoreceptor processes), off-axis (directional) OCT scans were acquired by altering the incident beam angle. Combined with on-axis (standard) line scans to yield HFL, true ONL and HFL thicknesses as well as ellipsoid zone (EZ) reflectivity were measured and compared between groups using a mixed-effects analysis.
RESULTS: Directional OCT revealed that true ONL comprises 63% of the presumed ONL thickness. Compared with healthy controls, the PD group showed a thicker true ONL and a thinner HFL (P < 0.05), whereas the combined ONL and HFL thickness was not different (P > 0.05). The EZ band exhibited lower reflectance in PD participants than healthy controls at the fovea and parafoveal regions (P < 0.05).
CONCLUSIONS: Directional OCT reveals that people with PD have a thicker photoreceptor nuclear layer and a thinner layer of photoreceptor processes. These opposing effects are not detectable using standard on-axis OCT alone. The EZ band is rich in mitochondria, and a lower reflectivity in PD participants may be indicative of metabolic changes in PD. These detailed examinations of the outer retina facilitate a deeper understanding of PD-related photoreceptor changes.