SNOR: a path for ribosome recovery after hibernation.

Cellular dormancy requires ribosomes to be reversibly silenced yet preserved. Gluc et al. identify Shwachman-Bodian-Diamond syndrome domain-containing hibernation factor (SNOR), a fission yeast hibernation factor induced specifically by perturbed glucose homeostasis. Rather than driving translational shutdown, SNOR maintains dormant ribosomes in a state competent for rapid reactivation.