International journal of surgery (London, England) · 2025
Endoscopic functional luminal imaging probe for intraprocedural guidance of achalasia treatment: a systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Fehervari Matyas, Middleton Isla, McGlone Emma Rose, Fadel Michael G, Brewer James, Patel Pranav, Hashemi Majid, Fakih-Gomez Naim, Kumar Sacheen
Аннотация
BACKGROUND: Functional luminal imaging probes (EndoFLIP) have shown potential as both diagnostic tools and intraoperative guides during achalasia interventions. This systematic review and meta-analysis aim to evaluate the intraoperative use of EndoFLIP during surgical procedures for achalasia, with a focus on its impact on the distensibility index (DI) and treatment outcomes.
MATERIALS AND METHODS: A literature search of Medline, Embase, and the Cochrane Library was conducted for studies reporting the use of EndoFLIP and DI in achalasia treatment from January 2000 to January 2024. Meta-analysis was performed using random-effect models to assess treatment effects, with heterogeneity between studies evaluated.
RESULTS: A total of 32 studies with 2681 patients were included in the qualitative synthesis, and 17 studies with 1734 patients were included in the quantitative synthesis. A pooled random-effects analysis demonstrated a significant reduction in DI following myotomy, with a weighted mean difference (WMD) of -3.72 (95% CI: -4.16 to -3.28; I2 = 90%). The Eckardt score analysis, including data from 1009 patients, showed a significant reduction by -5.21 (95% CI: -5.8 to -4.6; P < 0.001, I2 = 89.4%). The random-effects analysis of DI pre- and post-myotomy without an endoscope demonstrated a significant increase with a WMD of -2.402 (95% CI: -3.175 to -1.6; P < 0.001, I2 = 85.6%). A larger WMD was observed with endoscope placement above the FLIP device, measuring -4.14 (95% CI: -5.4 to -2.8; P < 0.001, I2 = 91.2%). For the 30 mL balloon fill, the WMD in the DI post-myotomy was -2.89 (95% CI: -3.2 to -2.4; P < 0.001). For the 40 mL balloon fill, the WMD was -4.02 (95% CI: -4.8 to -3.1; P < 0.001).
CONCLUSIONS: EndoFLIP enhances achalasia treatment by offering real-time feedback on the DI, allowing for more tailored interventions and improved outcomes. A standardized protocol for EndoFLIP usage is necessary to further validate its role in clinical practice and ensure consistent, comparable measurements.
MATERIALS AND METHODS: A literature search of Medline, Embase, and the Cochrane Library was conducted for studies reporting the use of EndoFLIP and DI in achalasia treatment from January 2000 to January 2024. Meta-analysis was performed using random-effect models to assess treatment effects, with heterogeneity between studies evaluated.
RESULTS: A total of 32 studies with 2681 patients were included in the qualitative synthesis, and 17 studies with 1734 patients were included in the quantitative synthesis. A pooled random-effects analysis demonstrated a significant reduction in DI following myotomy, with a weighted mean difference (WMD) of -3.72 (95% CI: -4.16 to -3.28; I2 = 90%). The Eckardt score analysis, including data from 1009 patients, showed a significant reduction by -5.21 (95% CI: -5.8 to -4.6; P < 0.001, I2 = 89.4%). The random-effects analysis of DI pre- and post-myotomy without an endoscope demonstrated a significant increase with a WMD of -2.402 (95% CI: -3.175 to -1.6; P < 0.001, I2 = 85.6%). A larger WMD was observed with endoscope placement above the FLIP device, measuring -4.14 (95% CI: -5.4 to -2.8; P < 0.001, I2 = 91.2%). For the 30 mL balloon fill, the WMD in the DI post-myotomy was -2.89 (95% CI: -3.2 to -2.4; P < 0.001). For the 40 mL balloon fill, the WMD was -4.02 (95% CI: -4.8 to -3.1; P < 0.001).
CONCLUSIONS: EndoFLIP enhances achalasia treatment by offering real-time feedback on the DI, allowing for more tailored interventions and improved outcomes. A standardized protocol for EndoFLIP usage is necessary to further validate its role in clinical practice and ensure consistent, comparable measurements.