Future Directions in Managing and Treating Laryngopharyngeal Reflux Disease for Improving Patient Care.

The etiologic mechanisms associated with the occurrence of pharyngeal reflux events, and the development of laryngopharyngeal reflux disease (LPRD) remains incompletely understood. A transversal and multidimensional approach evaluating diet, autonomic nerve dysfunction, gastroesophageal motility, microbiome alteration, and concentration of gastroduodenal enzymes in the ear, nose, and throat mucosa is needed. In addition, development of artificial intelligence software could improve selection of more personalized treatments and pretreatment to posttreatment clinical evaluations. However, the unawareness of LPRD in medicine and surgery remains the primary limiting factor for improving current LPRD knowledge and patient care.