International journal of dermatology · 2006
Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris.
Сравнительное исследованиеКонтролируемое клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Iraji Fariba, Yoosefi AliReza
Аннотация
BACKGROUND: The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation.
AIMS: This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV.
METHODS: In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared.
RESULTS: The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 +/- 1.7 vs. 24.4 +/- 3.3, P < 0.001).
CONCLUSIONS: Pilocarpine gel effectively treats PV.
AIMS: This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV.
METHODS: In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared.
RESULTS: The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 +/- 1.7 vs. 24.4 +/- 3.3, P < 0.001).
CONCLUSIONS: Pilocarpine gel effectively treats PV.