Romanian journal of internal medicine = Revue roumaine de medecine interne · 2025
Pancreatic stone protein predicts hospital stay in community-acquired infections.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Michailides Christos, Lagadinou Maria, Georgopoulou Eleni, Kechagia Eirini, Velissari Eleni-Konstantina, Polychronopoulos Nikolaos, Tasouli Foteini, Chatzigrigoriadis Christodoulos, Velissaris Dimitrios, Marangos Markos
Аннотация
BACKGROUND: Pancreatic Stone Protein (PSP) is an emerging biomarker for early detection and outcome prediction in infection and sepsis.
OBJECTIVE: To evaluate the association between PSP plasma measurements on Emergency Department (ED) admission and subsequent hospital length of stay (LOS) among adults with community-acquired infections.
METHODS: In this prospective observational study, 101 patients presenting to the ED with community-acquired respiratory, urinary or intra-abdominal infections had PSP measured within one hour of presentation. The primary outcome was hospital LOS (days). Association between PSP and LOS was assessed using Spearman's rank correlation. A linear regression analysis was performed demonstrating that only PSP levels were significantly associated with prolonged hospitalization, while LOS was compared between PSP groups (< 50 ng/ml vs ≥ 50 ng/ml).
RESULTS: PSP plasma levels were positively correlated with LOS (Spearman's ρ = 0.369, p < 0.001). Median LOS was 4 days in the PSP < 50 ng/ml group and 9 days in the PSP ≥ 50 ng/ml group (p < 0.001).
CONCLUSIONS: Elevated plasma PSP levels on ED admission were associated with increased hospital stay in patients with community-acquired infections. A PSP threshold of ≥ 50 ng/ml identified patients at higher risk for prolonged hospitalization. These results suggest that PSP could be a useful biomarker for early risk stratification and resource planning, although threshold validation and multivariable adjustment for confounding are needed.
OBJECTIVE: To evaluate the association between PSP plasma measurements on Emergency Department (ED) admission and subsequent hospital length of stay (LOS) among adults with community-acquired infections.
METHODS: In this prospective observational study, 101 patients presenting to the ED with community-acquired respiratory, urinary or intra-abdominal infections had PSP measured within one hour of presentation. The primary outcome was hospital LOS (days). Association between PSP and LOS was assessed using Spearman's rank correlation. A linear regression analysis was performed demonstrating that only PSP levels were significantly associated with prolonged hospitalization, while LOS was compared between PSP groups (< 50 ng/ml vs ≥ 50 ng/ml).
RESULTS: PSP plasma levels were positively correlated with LOS (Spearman's ρ = 0.369, p < 0.001). Median LOS was 4 days in the PSP < 50 ng/ml group and 9 days in the PSP ≥ 50 ng/ml group (p < 0.001).
CONCLUSIONS: Elevated plasma PSP levels on ED admission were associated with increased hospital stay in patients with community-acquired infections. A PSP threshold of ≥ 50 ng/ml identified patients at higher risk for prolonged hospitalization. These results suggest that PSP could be a useful biomarker for early risk stratification and resource planning, although threshold validation and multivariable adjustment for confounding are needed.