Default mode network dynamic functional network connectivity predicts psychotic symptom severity.

Neuropsychiatric disorders affect millions of people worldwide every year. Recent studies showed that the symptomatic overlaps across neuropsychiatric disorders mislead schizophrenia and bipolar disorder diagnosis. Additionally, recent studies claimed that schizoaffective disorder as a condition overlapped with both schizophrenia and bipolar disorder. Since symptomatic overlap among these disorders causes misdiagnosis, a need for neuroimaging biomarkers differentiating these disorders for a more accurate diagnosis is crucial. This study investigates dynamics functional network connectivity (dFNC) in the default mode network (DMN) of schizophrenia, bipolar, and schizoaffective disorder patients and compares them with their relative and healthy control. Additionally, it explored whether DMN dFNC features can predict the symptom severity of these neuropsychiatric disorders. Here, we found that dFNC features can differentiate schizophrenia from bipolar disorder. At the same time, we did not see a significant difference between schizoaffective with other conditions. Additionally, we found dFNC features can predict symptom severity of these three conditions.