Ophthalmology · 2010
Decision trees for indication of cataract surgery based on changes in visual acuity.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Quintana José M, Arostegui Inmaculada, Alberdi Txomin, Escobar Antonio, Perea Emilio, Navarro Gema, Elizalde Belen, Andradas Elena, IRYSS-Cataract Group
Аннотация
OBJECTIVE: To develop decision trees based on prospectively collected data for determining the appropriateness of cataract extraction.
DESIGN: Prospective observational cohort study.
PARTICIPANTS: Consecutive patients with a diagnosis of cataract who are on waiting lists to undergo cataract extraction by phacoemulsification.
METHODS: Patients were randomly assigned to 1 of 2 independent cohorts: The derivation cohort included 3691 patients, and the validation cohort included 2416 patients. Sociodemographic and clinical data, including visual acuity (VA) and the Visual Function Index 14 (VF-14), were collected before and after cataract extraction. Univariate and multivariate linear regression, and regression trees analysis were performed in the derivation cohort. Decision trees obtained in the derivation cohort were validated in the validation cohort. Final results were divided into appropriate or inappropriate indications and compared with a previously established benchmark of desirable VA and VF-14 gain in relation to preintervention VA classes.
MAIN OUTCOME MEASURES: Preintervention VA and changes 6 weeks after the intervention.
RESULTS: Among patients with simple cataract, predictors of significant improvement in VA after cataract extraction were preintervention VA and negative surgical complexity. Among patients with cataract and other ocular comorbidity, preintervention visual function and expected postintervention VA also predicted change in VA. When compared with a benchmark based on the minimal clinically important difference in VA after cataract extraction, sensitivity for the decision trees was 83% for both diagnostic groups and specificities ranged from 36.2 to 54.8.
CONCLUSIONS: A simple decision tree based on changes in VA can help identify appropriate patients for cataract extraction and be used to evaluate clinical practice or for quality control.
DESIGN: Prospective observational cohort study.
PARTICIPANTS: Consecutive patients with a diagnosis of cataract who are on waiting lists to undergo cataract extraction by phacoemulsification.
METHODS: Patients were randomly assigned to 1 of 2 independent cohorts: The derivation cohort included 3691 patients, and the validation cohort included 2416 patients. Sociodemographic and clinical data, including visual acuity (VA) and the Visual Function Index 14 (VF-14), were collected before and after cataract extraction. Univariate and multivariate linear regression, and regression trees analysis were performed in the derivation cohort. Decision trees obtained in the derivation cohort were validated in the validation cohort. Final results were divided into appropriate or inappropriate indications and compared with a previously established benchmark of desirable VA and VF-14 gain in relation to preintervention VA classes.
MAIN OUTCOME MEASURES: Preintervention VA and changes 6 weeks after the intervention.
RESULTS: Among patients with simple cataract, predictors of significant improvement in VA after cataract extraction were preintervention VA and negative surgical complexity. Among patients with cataract and other ocular comorbidity, preintervention visual function and expected postintervention VA also predicted change in VA. When compared with a benchmark based on the minimal clinically important difference in VA after cataract extraction, sensitivity for the decision trees was 83% for both diagnostic groups and specificities ranged from 36.2 to 54.8.
CONCLUSIONS: A simple decision tree based on changes in VA can help identify appropriate patients for cataract extraction and be used to evaluate clinical practice or for quality control.