Archives of ophthalmology (Chicago, Ill. : 1960) · 1995
Anterior ischemic optic neuropathy secondary to interferon alfa.
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Purvin V A
Аннотация
OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.
DESIGN: Description of the clinical findings in two patients with this condition.
SETTING: A neuro-ophthalmology referral center.
PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.
INTERVENTIONS: Treatment with aspirin and prednisone in one patient.
MAIN OUTCOME MEASURES: Visual acuity, color vision, Goldmann perimetry testing, and fundus photography.
RESULTS: Visual loss was mild and generally nonprogressive. The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa. The underlying pathogenesis is probably multifactorial.
DESIGN: Description of the clinical findings in two patients with this condition.
SETTING: A neuro-ophthalmology referral center.
PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.
INTERVENTIONS: Treatment with aspirin and prednisone in one patient.
MAIN OUTCOME MEASURES: Visual acuity, color vision, Goldmann perimetry testing, and fundus photography.
RESULTS: Visual loss was mild and generally nonprogressive. The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa. The underlying pathogenesis is probably multifactorial.