Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome.
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Rognoni Teresa, Fernández-Matarrubia Marta, Martinez-González Miguel Ángel, Salas-Salvadó Jordi, Corella Dolores, Castañer Olga, Martínez J Alfredo, Alonso-Gómez Ángel M, Gómez-Gracia Enrique, Vioque Jesús, Romaguera Dora, López-Miranda José, Estruch Ramón, Tinahones Francisco J, Santos-Lozano José Manuel, Serra-Majem Lluis, Cano Ibañez Naomi, Tur Josep A, Micó Pérez Rafael, Pintó Xavier, Delgado-Rodríguez Miguel, Ortiz Ramos María, Vidal Josep, Vázquez Clotilde, Daimiel Lidia, Ros Emilio, Goñi-Ruiz Nuria, Babio Nancy, Sorlí José V, Schröder Helmut, García-Rios Antonio, Compañ-Gabucio Laura, Warnberg Julia, Zulet M Ángeles, Chaplin Alice, Sacanella Emilio, Bouzalmate-Hajjaj Amira, Tojal-Sierra Lucas, Damas-Fuentes Miguel, Vázquez Zenaida, Gómez-Martínez Carlos, Saiz Carmen, Malcampo Mireia, Ortiz-Morales Ana M, Martínez-Avilés Vanessa, García-Gavilan Jesús, Abete Itziar, Fitó Montserrat, Toledo Estefanía
Аннотация
OBJECTIVE: To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome.
METHODS: Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3% ) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up. PA was quantified using the Minnesota questionnaire-shortened version. Cognitive function was evaluated using a battery of tests: Mini-Mental Test Examination, Clock Drawing Test, Trail Making Test A and B, Verbal Fluency Test, and Digit Span. The primary outcome was two-year change in cognition, measured through the Global Composite Score (GCS) of all neuropsychological tests. Multivariable-adjusted linear regression models were fitted with baseline PA and their changes as the main exposures and changes in cognitive function as the outcome.
RESULTS: No significant association was found between PA levels (or their changes) in the GCS of cognitive function. A greater increase in PA levels was associated with a more favorable two-year change in the Trail Making Test A (Q4 versus Q1: b = - 2.24s, 95% CI -4.36 to -0.12s; p-trend = 0.020). No significant association was found for other neuropsychological test.
CONCLUSION: Our results do not support an association between increases in PA and the evolution of the global cognitive function at two-year in an intervention trial which included PA promotion in one of its two randomized arms, but they suggested a possible beneficial effect of PA on attentional function in older adults.