Vaccination trial against experimental trichrinellosis using autoclaved Trichinella spiralis larvae vaccine (ATSLV).

The autoclaved Trichinella spiralis larvae vaccine (ATSLV) was tested and showed a surprising and somewhat unpredictable effect on the immune system of mice experimentally infected with T. spiralis. The vaccine was given with Bacille Calmette Guerin (BCG) as an adjuvant at different durations and by different routes of administration. The best result was achieved by given the vaccine twice intradermally with two weeks interval, as evidenced by a significant reduction in adult and larval count, as well as reproductive capacity index. Histopathologically, there was significant reduction in number of the encysted larvae which showed degeneration and hyalinization of the cyst wall accompanied by early pericystic fibrosis.