Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases · 1999
[Immunoregulation of IL-2 in Trichinella-infected mice].
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Niu C, Jiang H, Huang S, Zhu X
Аннотация
AIM: To study the immunoregulation of IL-2 in Trichinella-infected mice.
METHODS: Mice infected respectively with HL strain and AM strain larvae of Trichinella spiralis were treated i.p. with IL-2 from the second day postinfection for 3 days. Serum IgG antibody levels were determined by ELISA and the infection capacity was determined using reproductive capacity index (RCI).
RESULTS: In HL, higher dosage of IL-2 injection induced lower RCI and showed apparent anti-Trichinella effect. In AM, both low and high dose of IL-2 had no measurable effect on RCI, however, high dose of IL-2 reduced the infectivity of newborn larvae.
CONCLUSION: IL-2 exhibits apparent suppressive effect on the infectivity of T. spiralis of HL strain.
METHODS: Mice infected respectively with HL strain and AM strain larvae of Trichinella spiralis were treated i.p. with IL-2 from the second day postinfection for 3 days. Serum IgG antibody levels were determined by ELISA and the infection capacity was determined using reproductive capacity index (RCI).
RESULTS: In HL, higher dosage of IL-2 injection induced lower RCI and showed apparent anti-Trichinella effect. In AM, both low and high dose of IL-2 had no measurable effect on RCI, however, high dose of IL-2 reduced the infectivity of newborn larvae.
CONCLUSION: IL-2 exhibits apparent suppressive effect on the infectivity of T. spiralis of HL strain.