Emerging infectious diseases · 2025
Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Van Os Luc, Cassoux Nathalie, Cholidis Symira, Dureau Pascal, Farassat Navid, Fierz Fabienne Catherine, Ghyczy Ebba, Nitulescu Elena-Cristina, Stifter Eva, Tassignon Marie-José, Le Flèche-Matéos Anne, Lorenz Birgit, Spiroplasma Infantile Cataract Group
Аннотация
Spiroplasma ixodetis has been reported to cause the rare combination of cataract and uveitis in infants. Through a retrospective analysis of available literature and additional unpublished cases, we identified 28 eyes from 18 infants from 8 countries in Europe with cataracts and intraocular inflammation. The cataracts were bilateral in 55.6%, unilateral in 44.4%, and progressive in 46.4% of patients. Granulomatous anterior uveitis was found in all infants. Presence of S. ixodetis was supported by PCR (positive in 89.3% of eyes tested), transmission electron microscopy (positive in 90% of eyes tested), or culture of aspirated lens material (positive in 87.5% of eyes tested). Treatment with macrolide antimicrobial drugs, corticosteroids, and lensectomy appeared to be effective. Two patients had a recurrence of the uveitis after lens extraction and needed prolonged treatment. To increase awareness of S. ixodetis, we suggest its inclusion with the organisms of the TORCH acronym.