Clinical and vaccine immunology : CVI · 2007
Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16.
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Fujiwara Ricardo T, Zhan Bin, Mendez Susana, Loukas Alex, Bueno Lilian L, Wang Yan, Plieskatt Jordan, Oksov Yelena, Lustigman Sara, Bottazzi Maria Elena, Hotez Peter, Bethony Jeffrey M
Аннотация
Hookworm infection is one of most important parasitic infection of humans, occurring in 740 million people. Here we report the protective vaccination of dogs with Ac-16, an immunodominant surface antigen from the hookworm Ancylostoma caninum. We show that immunization with Ac-16 formulated with AS03 elicited specific humoral and cellular immune responses and provided partial protection against hookworm infection and morbidity as evidenced by a significant reduction of hookworm egg counts (64% reduction; P = 0.0078) and worm-induced blood loss (P < 0.05). Moreover, specific anti-Ac-16 antibodies recognized the native protein on the surface of third-stage larvae and blocked their migration through tissue in vitro. Our data support the use of Ac-16 as a potential candidate for vaccination against hookworm infection.