Clinical endocrinology · 2014
Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study.
СтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен
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Delitala Alessandro P, Orrù Marco, Filigheddu Fabiana, Pilia Maria Grazia, Delitala Giuseppe, Ganau Antonello, Saba Pier Sergio, Decandia Federica, Scuteri Angelo, Marongiu Michele, Lakatta Edward G, Strait James, Cucca Francesco
Аннотация
OBJECTIVE: Thyroid dysfunction may accelerate atherosclerosis. Aortic pulse wave velocity (PWV) is an early index of arterial stiffness and an important risk factor for cardiovascular disease and might therefore be linked to changes in thyroid activity. We investigated the relationship between thyroid function and carotid-femoral PWV, as an index of arterial stiffness.
DESIGN: Cross-sectional cohort study.
PATIENTS: Participants from the SardiNIA study. Those being treated for thyroid diseases were excluded, yielding a sample of 5875 aged 14-102.
MEASUREMENTS: Clinical parameters, blood tests including serum TSH and serum FT4, and carotid-femoral PWV were measured.
RESULTS: After adjusting for confounders, a direct and linear association between FT4 and PWV was shown (multiple regression analysis). The model containing age, mean blood pressure, body mass index, heart rate, FT4, hypertension, diabetes and dyslipidaemia accounted for 55% of the variation in PWV.
CONCLUSIONS: Like several other known risk factors, serum FT4 levels are associated with carotid-femoral PWV, suggesting that high FT4 levels have a detrimental effect on aortic stiffness and may contribute to ageing process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy.
DESIGN: Cross-sectional cohort study.
PATIENTS: Participants from the SardiNIA study. Those being treated for thyroid diseases were excluded, yielding a sample of 5875 aged 14-102.
MEASUREMENTS: Clinical parameters, blood tests including serum TSH and serum FT4, and carotid-femoral PWV were measured.
RESULTS: After adjusting for confounders, a direct and linear association between FT4 and PWV was shown (multiple regression analysis). The model containing age, mean blood pressure, body mass index, heart rate, FT4, hypertension, diabetes and dyslipidaemia accounted for 55% of the variation in PWV.
CONCLUSIONS: Like several other known risk factors, serum FT4 levels are associated with carotid-femoral PWV, suggesting that high FT4 levels have a detrimental effect on aortic stiffness and may contribute to ageing process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAortaAtherosclerosisBody Mass IndexCardiovascular DiseasesCarotid ArteriesDyslipidemiasFemaleFemoral ArteryHeart RateHumansHyperthyroidismItalyMaleMiddle AgedPulse Wave AnalysisRegression AnalysisRisk FactorsThyroid Function TestsThyroid GlandThyrotropinThyroxineVascular Stiffness