Nature genetics · 2019

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

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Karlsson Linnér Richard, Biroli Pietro, Kong Edward, Meddens S Fleur W, Wedow Robbee, Fontana Mark Alan, Lebreton Maël, Tino Stephen P, Abdellaoui Abdel, Hammerschlag Anke R, Nivard Michel G, Okbay Aysu, Rietveld Cornelius A, Timshel Pascal N, Trzaskowski Maciej, Vlaming Ronald de, Zünd Christian L, Bao Yanchun, Buzdugan Laura, Caplin Ann H, Chen Chia-Yen, Eibich Peter, Fontanillas Pierre, Gonzalez Juan R, Joshi Peter K, Karhunen Ville, Kleinman Aaron, Levin Remy Z, Lill Christina M, Meddens Gerardus A, Muntané Gerard, Sanchez-Roige Sandra, Rooij Frank J van, Taskesen Erdogan, Wu Yang, Zhang Futao, 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium, Social Science Genetic Association Consortium, Auton Adam, Boardman Jason D, Clark David W, Conlin Andrew, Dolan Conor C, Fischbacher Urs, Groenen Patrick J F, Harris Kathleen Mullan, Hasler Gregor, Hofman Albert, Ikram Mohammad A, Jain Sonia, Karlsson Robert, Kessler Ronald C, Kooyman Maarten, MacKillop James, Männikkö Minna, Morcillo-Suarez Carlos, McQueen Matthew B, Schmidt Klaus M, Smart Melissa C, Sutter Matthias, Thurik A Roy, Uitterlinden André G, White Jon, Wit Harriet de, Yang Jian, Bertram Lars, Boomsma Dorret I, Esko Tõnu, Fehr Ernst, Hinds David A, Johannesson Magnus, Kumari Meena, Laibson David, Magnusson Patrik K E, Meyer Michelle N, Navarro Arcadi, Palmer Abraham A, Pers Tune H, Posthuma Danielle, Schunk Daniel, Stein Murray B, Svento Rauli, Tiemeier Henning, Timmers Paul R H J, Turley Patrick, Ursano Robert J, Wagner Gert G, Wilson James F, Gratten Jacob, Lee James J, Cesarini David, Benjamin Daniel J, Koellinger Philipp D, Beauchamp Jonathan P

Аннотация

Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

Предметные рубрики MeSH

Behavior Case-Control Studies Female Genetic Loci Genetic Predisposition to Disease Genetics, Behavioral Genome-Wide Association Study Genotype Humans Male Polymorphism, Single Nucleotide

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

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Аннотация

Предметные рубрики MeSH