Evolution of hepatitis B virus surface gene and protein among Iranian chronic carriers from different provinces.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Ramezani Fatemeh, Alavian Seyed Moayed, Sadeghi Ahmadreza, Khedive Abolfazl, Ghalichi Leila, Norouzi Mehdi, Karimzadeh Hadi, Malekzadeh Reza, Montazeri Ghodrat, Nejatizadeh Azim, Ziaee Masood, Abedi Farshid, Ataei Behrooz, Yaran Majid, Sayad Babak, Somi Mohamad Hosein, Sarizadeh Gholamreza, Sanei-Moghaddam Ismail, Mansour-Ghanaei Fariborz, Rafatpanah Houshang, Keyvani Hossein, Kalantari Ebrahim, Saberfiroozi Mehdi, Rezaee Reza, Daram Maryam, Mahabadi Mostafa, Goodarzi Zahra, Poortahmasebi Vahdat, Geravand Babak, Khamseh Azam, Mahmoodi Masoud, Jazayeri Seyed Mohammad
Аннотация
MATERIALS AND METHODS: Sera obtained from 360 isolates from 12 Different regions of country were used for amplification and sequencing of surface proteins. A detailed mutational analysis was undertaken.
RESULTS: The total ratio for Missense/Silent nucleotide substitutions was 0.96. Sistan and Kermanshah showed the lowest rate of evolution between provinces (P = 0.055). On the other hand, Khorasan Razavi and Khoozestan contained the highest ratio (P = 0.055). The rest of regions were laid between these two extremes. Azarbayjan and Guilan showed the highest proportion of immune epitope distribution (91.3% and 96%, respectively). Conversely, Sistan and Tehran harbored the least percentage (66.6% and 68.8%, respectively). Kermanshah province contained only 5.2%, whereas Isfahan had 54.5% of B cell epitope distribution. In terms of T helper epitopes, all provinces showed a somehow homogeneity: 22.58% (Fars) to 46.6% (Khuzestan). On the other hand, distribution of substitutions within the CTL epitopes showed a wide range of variation between 6.6% (Khuzestan) and 63% (Kermanshah).
CONCLUSION: Further to low selection pressure found in Iranian population, the variations between different regions designate random genetic drift within the surface proteins. These finding would have some applications in terms of specific antiviral regimen, design of more efficient vaccine and public health issues.