Journal of perinatology : official journal of the California Perinatal Association · 2025
Dexmedetomidine's effect on neonatal sedation, pain, respiratory status and cardiovascular system.
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Makoni Marjorie M, Sierra-Strum Ivonne, Bischoff Adrianne R, Miller Jamie L, DeShea Lise, Beasley William Howard, Szyld Edgardo
Аннотация
OBJECTIVE: To describe the effects of dexmedetomidine on sedation, pain, respiratory status, and hemodynamics in neonates.
METHODS: A retrospective study of 206 infants in a level IV NICU (2016-2021) receiving continuous dexmedetomidine infusion. Pain/sedation scores, BP, vasopressor and inotrope score (VIS), and concomitant sedatives/analgesics (CSA) were recorded before and every 3-4 h for 24 h.
RESULTS: Median PMA:32 weeks. Hypotension occurred in 26%, primarily in infants <32weeks PMA, correlating with higher VIS and CSA. CSA use significantly predicted vasopressors/inotrope use.
CONCLUSION: Dexmedetomidine, with CSA, increases cardiovascular instability in preterm infants who have unique myocardial structure and function and therefore higher vulnerability.
CLINICAL TRIAL REGISTRATION (IF ANY): None (not applicable).
METHODS: A retrospective study of 206 infants in a level IV NICU (2016-2021) receiving continuous dexmedetomidine infusion. Pain/sedation scores, BP, vasopressor and inotrope score (VIS), and concomitant sedatives/analgesics (CSA) were recorded before and every 3-4 h for 24 h.
RESULTS: Median PMA:32 weeks. Hypotension occurred in 26%, primarily in infants <32weeks PMA, correlating with higher VIS and CSA. CSA use significantly predicted vasopressors/inotrope use.
CONCLUSION: Dexmedetomidine, with CSA, increases cardiovascular instability in preterm infants who have unique myocardial structure and function and therefore higher vulnerability.
CLINICAL TRIAL REGISTRATION (IF ANY): None (not applicable).