Internal medicine (Tokyo, Japan) · 2024
Primary Adrenal Insufficiency Triggered by Cytomegalovirus Infection after Obinutuzumab Plus Bendamustine Therapy for Follicular Lymphoma.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Nakamura Takashi, Uryu Hideki, Kawashima Ryutaro, Ishiguro Mizuki, Tanizawa Mika, Kanazawa Yasushi, Yamazaki Hiroyuki, Yahagi Yuichi
Аннотация
A 69-year-old man was diagnosed with follicular lymphoma (grade 3A). Obinutuzumab combined with bendamustine (OB) therapy was initiated as salvage chemotherapy. Nausea, abdominal pain, and hyponatremia appeared after six courses of OB therapy; cytomegalovirus (CMV) enteritis with primary adrenal insufficiency (PAI) was a complication. Ganciclovir and hydrocortisone were administered, and the clinical findings improved. PAI caused by CMV infection has mainly been reported in patients with acquired immunodeficiency syndrome. In the present case, the PAI triggered by CMV infection led to immunodeficiency after chemotherapy.