Sleep medicine · 2026
Physiologic and symptomatic burden across sleep-disordered breathing severity in men and women.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hurst MaryKathryn, Aurora R Nisha, Stefanovski Darko, Punjabi Naresh M
Аннотация
BACKGROUND: Sex differences in sleep-disordered breathing (SDB) are well recognized, but whether equivalent disease severity confers similar physiologic and symptomatic burden remains uncertain.
METHODS: Data from a community-based cohort of 826 adults free of major cardiopulmonary and metabolic comorbidity were analyzed. Study participants were classified as having no SDB (apnea-hypopnea index [AHI] <5 events/h), mild SDB (5.0-14.9 events/h), or moderate-to-severe SDB (≥15 events/h). Within each stratum, men and women were matched 1:1 on age, race, body mass index, and AHI. Objective polysomnographic measures and subjective assessments of daytime sleepiness, insomnia symptoms, and quality of life were compared using regression models with sex-by-severity interaction terms.
RESULTS: Objective sleep measures were largely similar between sexes in the absence of SDB. With mild SDB, men slept 22.2 min less than women (p = 0.006) and had higher overall and NREM arousal rates (p = 0.002 and p = 0.001, respectively). With moderate-to-severe SDB, men had lower sleep efficiency (-8.6%; p < 0.001), longer wake after sleep onset (+22.7 min; p = 0.001), and greater daytime sleepiness (p = 0.06), whereas women had more insomnia symptoms and lower physical and mental quality-of-life scores (both p = 0.001). Across all AHI strata, women had greater N3 sleep (all p < 0.003). Significant sex-by-severity interactions were observed for sleep efficiency, wake after sleep onset, and daytime sleepiness (all p ≤ 0.006).
CONCLUSION: Comparable levels of SDB severity carry different physiologic and symptomatic consequences in men and women, indicating that assessment should extend beyond AHI alone to include sleep disruption, symptom profile, and functional impact.
METHODS: Data from a community-based cohort of 826 adults free of major cardiopulmonary and metabolic comorbidity were analyzed. Study participants were classified as having no SDB (apnea-hypopnea index [AHI] <5 events/h), mild SDB (5.0-14.9 events/h), or moderate-to-severe SDB (≥15 events/h). Within each stratum, men and women were matched 1:1 on age, race, body mass index, and AHI. Objective polysomnographic measures and subjective assessments of daytime sleepiness, insomnia symptoms, and quality of life were compared using regression models with sex-by-severity interaction terms.
RESULTS: Objective sleep measures were largely similar between sexes in the absence of SDB. With mild SDB, men slept 22.2 min less than women (p = 0.006) and had higher overall and NREM arousal rates (p = 0.002 and p = 0.001, respectively). With moderate-to-severe SDB, men had lower sleep efficiency (-8.6%; p < 0.001), longer wake after sleep onset (+22.7 min; p = 0.001), and greater daytime sleepiness (p = 0.06), whereas women had more insomnia symptoms and lower physical and mental quality-of-life scores (both p = 0.001). Across all AHI strata, women had greater N3 sleep (all p < 0.003). Significant sex-by-severity interactions were observed for sleep efficiency, wake after sleep onset, and daytime sleepiness (all p ≤ 0.006).
CONCLUSION: Comparable levels of SDB severity carry different physiologic and symptomatic consequences in men and women, indicating that assessment should extend beyond AHI alone to include sleep disruption, symptom profile, and functional impact.