The Etiology of Childhood Pneumonia in Bangladesh: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Brooks W Abdullah, Zaman Khalequ, Goswami Doli, Prosperi Christine, Endtz Hubert P, Hossain Lokman, Rahman Mustafizur, Ahmed Dilruba, Rahman Mohammed Ziaur, Banu Sayera, Shikder Arif Uddin, Jahan Yasmin, Nahar Kamrun, Chisti Mohammod Jobayer, Yunus Mohammed, Khan Muhammad Alfazal, Matin Fariha Bushra, Mazumder Razib, Shahriar Bin Elahi Mohammad, Saifullah Muhammad, Alam Muntasir, Bin Shahid Abu Sadat Mohammad Sayeem, Haque Fahim, Sultana Sabiha, Higdon Melissa M, Haddix Meredith, Feikin Daniel R, Murdoch David R, Hammitt Laura L, O'Brien Katherine L, Deloria Knoll Maria
Аннотация
METHODS: As part of the Pneumonia Etiology Research for Child Health study, we enrolled children 1-59 months of age with World Health Organization-defined severe and very severe pneumonia, plus age-frequency-matched controls, in Matlab and Dhaka, Bangladesh. We applied microbiologic methods to nasopharyngeal/oropharyngeal swabs, blood, induced sputum, gastric and lung aspirates. Etiology was estimated using Bayesian methods that integrated case and control data and accounted for imperfect sensitivity and specificity of the measurements.
RESULTS: We enrolled 525 cases and 772 controls over 24 months. Of the cases, 9.1% had very severe pneumonia and 42.0% (N = 219) had infiltrates on chest radiograph. Three cases (1.5%) had positive blood cultures (2 Salmonella typhi, 1 Escherichia coli and Klebsiella pneumoniae). All 4 lung aspirates were negative. The etiology among chest radiograph-positive cases was predominantly viral [77.7%, 95% credible interval (CrI): 65.3-88.6], primarily respiratory syncytial virus (31.2%, 95% CrI: 24.7-39.3). Influenza virus had very low estimated etiology (0.6%, 95% CrI: 0.0-2.3). Mycobacterium tuberculosis (3.6%, 95% CrI: 0.5-11.0), Enterobacteriaceae (3.0%, 95% CrI: 0.5-10.0) and Streptococcus pneumoniae (1.8%, 95% CrI: 0.0-5.9) were the only nonviral pathogens in the top 10 etiologies.
CONCLUSIONS: Childhood severe and very severe pneumonia in young children in Bangladesh is predominantly viral, notably respiratory syncytial virus.