Frontiers in microbiology · 2020
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
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Sedrakyan Anahit M, Ktsoyan Zhanna A, Arakelova Karine A, Zakharyan Magdalina K, Hovhannisyan Alvard I, Gevorgyan Zaruhi U, Mnatsakanyan Armine A, Kakabadze Elene G, Makalatia Khatuna B, Chanishvili Nina A, Pirnay Jean-Paul, Arakelyan Arsen A, Aminov Rustam I
Аннотация
A total of 291 non-duplicate isolates of non-typhoidal Salmonella (NTS) were collected from the fecal samples of patients with salmonellosis in Armenia and Georgia during 1996-2016. The isolates were tested for resistance to antimicrobials, including extended-spectrum β-lactamases (ESBL). The high prevalence of multidrug-resistance (MDR) and ESBL-producer phenotypes was detected among Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) isolates collected from patients in Armenia between 1996 and 2016. A total of 36 MDR NTS isolates were subjected to whole genome sequencing (WGS) to determine the genetic background of antimicrobial resistance (AMR) and mobile genetic elements. All ESBL-producing S. Typhimurium isolates belonged to the same sequence type (ST328). The ESBL-producer phenotype was associated with plasmid-encoded CTX-M-5 production. A range of other plasmids was associated with resistance to other antimicrobials, including the MDR phenotype.