Lower rate of pancreatobiliary complications after sludge and microlithiasis pancreatitis compared to gallstone pancreatitis.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Sirtl Simon, Teodorescu Bianca, Gilberg Leonard, Schäfer Arlett, Beyer Georg, Arnau Anna, López-Guillén Pablo, Martínez-Domínguez Samuel J, Baroja Daniel Abad, Oyón Daniel, Ruiz-Belmonte Lara M, Tejedor-Tejada Javier, Zapater Raul, Martín-Vicente Noelia, Fernández-Esparcia Pedro José, Gomara Ana Belén Julián, Lozano Violeta Sastre, García Juan José Manzanares, Martín-Falquina Irene Chivato, Pascual Laura Andrés, Monclus Nuria Torres, Velasco Natividad Zaragoza, Rojo Eukene, Lapeña-Muñoz Berta, Flores Virginia, Gómez Arantxa Díaz, Cañamares-Orbís Pablo, Abizanda Isabel Vinzo, Carrasco Natalia Marcos, Grau Laura Pardo, García-Rayado Guillermo, Bocos Judith Millastre, de Paredes Ana Garcia Garcia, Lorenzo María Vaamonde, Arostegi Arantzazu Izagirre, Lozada-Hernández Edgard Efrén, Velasco José Antonio Velarde-Ruiz, Żorniak Michal, de-Madaria Enrique, Mayerle Julia, Velamazán Raúl
Аннотация
METHODS: This analysis included 789 patients from the international, multicenter Relapstone cohort (Spain: 16 centers; Mexico: 2 centers), hospitalized between January 2018 and April 2020 with first-time biliary AP and no cholecystectomy during admission. Patients with sludge/microlithiasis-induced AP (n = 274) were compared to those with gallstone-induced AP (n = 515) regarding pancreatobiliary complications. Multivariate analysis was used to assess relapse risk factors.
RESULTS: Pancreatobiliary complications occurred in 41.7 % of the gallstone cohort versus 32.1 % in the sludge/microlithiasis cohort (p = 0.01). Correspondingly, the gallstone AP cohort showed a significantly lower complication-free survival rate (log-rank p = 0.0022; median follow-up: 6.1 vs. 8.1 months). In multivariate analysis, older age in the gallstone group was significantly associated with lower relapse risk (HR = 0.54, 95 % CI: 0.39-0.74).
CONCLUSION: This multicenter study reveals distinct differences in relapse risk between gallstone- and sludge/microlithiasis-induced AP, with gallstone AP showing a higher rate of complications in the absence of cholecystectomy.