European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
Application of systemic immune-inflammation index in survival prediction after radical resection of gallbladder cancer: A multicenter retrospective clinical study.
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Huang Zhenhao, Wang Jixing, Zhou Baoyong, Zhang Xiang, Liao Rui, Xu Jie, Guo Peng, Liu Zhipeng, You Nan, Tao Rui, Hu Qihui
Аннотация
BACKGROUND: The Systemic Immune-Inflammation Index (SII) is a novel biomarker reflecting immune and inflammatory status, increasingly used for prognostic evaluation in various cancers. Its prognostic value in gallbladder cancer (GBC) remains unclear. This study investigates SII as a predictor of postoperative survival in GBC patients undergoing radical resection.
METHODS: This retrospective study analyzed data from 210 GBC patients who underwent radical resection at six hospitals between 2015 and 2023. Time-dependent receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff value of SII for assessing 1-year overall survival (OS). The relationships between SII and clinicopathological features were analyzed using Pearson's chi-square test and Fisher's exact test. Survival curves were plotted using the Kaplan-Meier method, with univariate analysis identifying prognostic factors. Independent prognostic factors were evaluated using multivariate Cox proportional hazards models.
RESULTS: An SII cutoff of 590.105 stratified patients into low and high SII groups. High SII was significantly associated with worse OS and recurrence-free survival (RFS) (P < 0.05). Multivariate analysis identified SII, lymph node metastasis, and hemoglobin (Hb) as independent prognostic factors. The combined SII-Hb model (AUC = 0.774) demonstrated superior predictive performance compared to SII alone (AUC = 0.745).
CONCLUSIONS: This study indicates that a high SII value is a significant predictor of poor long-term prognosis in GBC patients. As a readily accessible biomarker, SII, when combined with Hb, enhances the predictive accuracy of postoperative survival assessment, providing a new tool and guidance for individualized management of GBC patients.
METHODS: This retrospective study analyzed data from 210 GBC patients who underwent radical resection at six hospitals between 2015 and 2023. Time-dependent receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff value of SII for assessing 1-year overall survival (OS). The relationships between SII and clinicopathological features were analyzed using Pearson's chi-square test and Fisher's exact test. Survival curves were plotted using the Kaplan-Meier method, with univariate analysis identifying prognostic factors. Independent prognostic factors were evaluated using multivariate Cox proportional hazards models.
RESULTS: An SII cutoff of 590.105 stratified patients into low and high SII groups. High SII was significantly associated with worse OS and recurrence-free survival (RFS) (P < 0.05). Multivariate analysis identified SII, lymph node metastasis, and hemoglobin (Hb) as independent prognostic factors. The combined SII-Hb model (AUC = 0.774) demonstrated superior predictive performance compared to SII alone (AUC = 0.745).
CONCLUSIONS: This study indicates that a high SII value is a significant predictor of poor long-term prognosis in GBC patients. As a readily accessible biomarker, SII, when combined with Hb, enhances the predictive accuracy of postoperative survival assessment, providing a new tool and guidance for individualized management of GBC patients.