South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2020
Postoperative infections: Aetiology, incidence and risk factors among neurosurgical patients in Mthatha, South Africa.
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Bokop Fotso C, Abaver D T, Muballe D, Vasaikar S, Apalata T
Аннотация
BACKGROUND: Despite progress in hospital care, infections continue to represent one of the major complications among hospitalised patients.
OBJECTIVES: To determine the aetiology and incidence of hospital-acquired infections and their associated risk factors following neurosurgical procedures.
METHODS: A retrospective study was conducted from October 2013 to September 2014. Data including demographics, hospitalisation period, type of operation and primary diagnosis were collected. Post-surgical infections were confirmed microbiologically. SPSS (Statistical Package for the Social Sciences) version 23 was used for statistical analysis.
RESULTS: Among a total of 1 688 patients who underwent neurosurgical operations, the incidence of post-surgical infections was 4.2% per year. Post-surgical infections were significantly associated with craniotomy (p<0.0001), prolonged stay in hospital (≥30 days) (p=0.008), and patient age ≥35 years (p=0.05). Staphylococcus aureus was the most frequently isolated pathogen (19.7%), followed by Klebsiella pneumoniae (12.7%). A total of 42.9% of S. aureus isolates were methicillin-resistant S. aureus (MRSA), but all these isolates were susceptible to vancomycin; 44.4% of K. pneumoniae isolates were extended-spectrum beta-lactamase (ESBL)-positive, but were susceptible to carbapenems, piperacillin-tazobactam and amikacin.
CONCLUSIONS: Post-surgical infections remain an important problem in neurosurgery. Increased resistance to causative pathogens is a major concern.
OBJECTIVES: To determine the aetiology and incidence of hospital-acquired infections and their associated risk factors following neurosurgical procedures.
METHODS: A retrospective study was conducted from October 2013 to September 2014. Data including demographics, hospitalisation period, type of operation and primary diagnosis were collected. Post-surgical infections were confirmed microbiologically. SPSS (Statistical Package for the Social Sciences) version 23 was used for statistical analysis.
RESULTS: Among a total of 1 688 patients who underwent neurosurgical operations, the incidence of post-surgical infections was 4.2% per year. Post-surgical infections were significantly associated with craniotomy (p<0.0001), prolonged stay in hospital (≥30 days) (p=0.008), and patient age ≥35 years (p=0.05). Staphylococcus aureus was the most frequently isolated pathogen (19.7%), followed by Klebsiella pneumoniae (12.7%). A total of 42.9% of S. aureus isolates were methicillin-resistant S. aureus (MRSA), but all these isolates were susceptible to vancomycin; 44.4% of K. pneumoniae isolates were extended-spectrum beta-lactamase (ESBL)-positive, but were susceptible to carbapenems, piperacillin-tazobactam and amikacin.
CONCLUSIONS: Post-surgical infections remain an important problem in neurosurgery. Increased resistance to causative pathogens is a major concern.
Предметные рубрики MeSH
AdolescentAge FactorsAnti-Bacterial AgentsCraniotomyCross InfectionCross-Sectional StudiesDrug Resistance, BacterialFemaleHumansIncidenceInfantInfant, NewbornKlebsiella InfectionsLength of StayMaleRetrospective StudiesRisk FactorsSouth AfricaStaphylococcal InfectionsSurgical Wound InfectionVentriculoperitoneal Shunt