Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 2025
[Two new sesquiterpenoids from Aucklandiae Radix and their farnesoid X receptor agonist activity].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Chen Qian-Yu, Huang Dan, Zhan Hong-Hong, Meng Fan-Cheng, Wang Guo-Wei, Chen Min
Аннотация
Various chromatographic methods were comprehensively applied to study the chemical composition of the ethyl acetate extract from Aucklandiae Radix. The structures of all compounds were identified by analyzing their physicochemical properties and using spectroscopic methods. Two new sesquiterpenoids, named auclappsines A and B(1 and 2) were isolated and identified. Through in vitro high content screening and with the use of a guggulsterone-induced L02 cells, the effects of 1 and 2 on farnesoid X receptor(FXR) protein expression were investigated. The results showed that 1 had a significant FXR activation effect, providing a scientific basis for the development of drugs for the treatment of liver and gallbladder diseases.