Genetics and molecular research : GMR · 2004
Drug resistance in Chromobacterium violaceum.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Fantinatti-Garboggini Fabiana, Almeida Rosana de, Portillo Vinícius do Amaral, Barbosa Tércio A P, Trevilato Peterson Beltramini, Neto Cícero Eduardo Ramalho, Coêlho Rosângela Duarte, Silva Denise Wanderlei, Bartoleti Luciana Aparecida, Hanna Ebert Seixas, Brocchi Marcelo, Manfio Gilson P
Аннотация
Chromobacterium violaceum is a free-living bacterium commonly found in aquatic habitats of tropical and subtropical regions of the world. This bacterium is able to produce a large variety of products of biotechnological and pharmacological use. Although C. violaceum is considered to be non-pathogenic, some cases of severe infections in humans and other animals have been reported. Genomic data on the type strain ATCC 12472(T) has provided a comprehensive basis for detailed studies of pathogenicity, virulence and drug resistance genes. A large number of open reading frames associated with various mechanisms of drug resistance were found, comprising a remarkable feature of this organism. Amongst these, beta-lactam (penicillin and cephalosporin) and multidrug resistance genes (drug efflux pumps) were the most numerous. In addition, genes associated with bacitracin, bicyclomycin, chloramphenicol, kasugamycin, and methylenomycin were also found. It is postulated that these genes contribute to the ability of C. violaceum to compete with other bacteria in the environment, and also may help to explain the common drug resistance phenotypes observed in infections caused by this bacterium.