Research in developmental disabilities · 2016
Specific executive control impairments in Tourette syndrome: The role of response inhibition.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yaniv Asaf, Benaroya-Milshtein Noa, Steinberg Tamar, Ruhrrman Dafna, Apter Alan, Lavidor Michal
Аннотация
BACKGROUND: Tourette syndrome (TS) is a childhood-onset disorder characterized by motor and vocal tics. While cognitive features of common comorbid conditions such as attention deficit hyperactive disorder and obsessive compulsive disorder have been widely investigated, the cognitive profile of TS patients remains to be precisely defined. In this regard, the executive functions system (EF) is of especial interest.
AIMS: The aim of the study was to delineate the various components of executive processes in adult TS patients.
METHODS: A sample of 19 adults diagnosed with TS and 19 age-matched control subjects underwent computerized battery of executive tasks, as well as block design and memory tests. All patients received a thorough clinical assessment with an emphasis on illness severity.
RESULTS: There was a marked impairment in response inhibition ability regardless of comorbid conditions, In addition, there was decreased accuracy in set shifting, but not in response time. These results imply that impaired response inhibition in the EF system is the primary cognitive impairment in TS and that many of the previously reported impaired executive functions in TS are secondary to this impairment.
CONCLUSIONS: This finding of impaired response inhibition in TS may imply that rehabilitation of this inhibition component could prove to be an important therapeutic strategy in adults with TS.
AIMS: The aim of the study was to delineate the various components of executive processes in adult TS patients.
METHODS: A sample of 19 adults diagnosed with TS and 19 age-matched control subjects underwent computerized battery of executive tasks, as well as block design and memory tests. All patients received a thorough clinical assessment with an emphasis on illness severity.
RESULTS: There was a marked impairment in response inhibition ability regardless of comorbid conditions, In addition, there was decreased accuracy in set shifting, but not in response time. These results imply that impaired response inhibition in the EF system is the primary cognitive impairment in TS and that many of the previously reported impaired executive functions in TS are secondary to this impairment.
CONCLUSIONS: This finding of impaired response inhibition in TS may imply that rehabilitation of this inhibition component could prove to be an important therapeutic strategy in adults with TS.