Tremor and other hyperkinetic movements (New York, N.Y.) · 2016
Post-mortem Findings in Huntington's Deep Brain Stimulation: A Moving Target Due to Atrophy.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Vedam-Mai Vinata, Martinez-Ramirez Daniel, Hilliard Justin D, Carbunaru Samuel, Yachnis Anthony T, Bloom Joshua, Keeling Peyton, Awe Lisa, Foote Kelly D, Okun Michael S
Аннотация
BACKGROUND: Deep brain stimulation (DBS) has been shown to be effective for Parkinson's disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington's disease (HD).
CASE REPORT: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized.
DISCUSSION: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.
CASE REPORT: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized.
DISCUSSION: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.