Journal of clinical anesthesia · 2026
Closed-loop versus manual vasopressor titration for blood pressure control in surgical and critically ill patients: A systematic review and meta-analysis of randomised trials.
СтатьяСистематический обзорМетаанализСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Chiou Katie, Patrick Philip, Srivastava Ishita, Engelman Edgard, Rinehart Joseph, Joosten Alexandre, Coeckelenbergh Sean
Аннотация
BACKGROUND: Perioperative hypotension is associated with myocardial injury, acute kidney injury, and mortality, yet manual vasopressor titration frequently results in suboptimal blood pressure (BP) control. Closed-loop vasopressor (CLV) systems use automated feedback algorithms to maintain predefined BP targets and may reduce haemodynamic variability while decreasing provider workload.
METHODS: We conducted a PRISMA-guided systematic review and meta-analysis on PubMed, CENTRAL, EMBASE, and Web of Science from inception to June 2025. Randomised controlled trials of adults receiving CLV or manual vasopressor titration in perioperative and critical care settings were included. The primary outcome was time below target; secondary outcomes included time within and above target, time in hypotension (MAP <65 mmHg), vasopressor consumption, and length of stay.
RESULTS: Eight trials with 640 patients were analysed, including five trials conducted in the operating room and three trials in the ICU. Compared with manual titration, CLV significantly reduced time below target (mean difference [MD] = -15.81%; 95% CI = -20.38 to -11.25%; p < 0.001; n = 176), increased time in target (MD = 30.18%; 95% CI = 21.91 to 38.44%; p < 0.001; n = 216), reduced time in hypotension (SMD = -0.90; 95% CI = -1.64 to -0.17; p = 0.02; I2 = 79%), and hospital length of stay (MD = -1.12 days; 95% CI = -2.21 to -0.04 days; p = 0.04; I2 = 0%; n = 158). The length of post-anaesthesia care unit-intensive care unit stay (MD = -0.05 min, 95% CI = -1.10 to 1.00 min; p = 0.93; I2 = 0%; n = 198) did not differ between the two groups.
CONCLUSION: In surgical and critically-ill patients, closed-loop systems were associated with improved adherence to predefined blood pressure targets with reduced time below target and increased time in target compared to manual vasopressor titration. Whether these haemodynamic improvements translate into beneficial impact on patient outcomes will require confirmation in large multicentre randomised trials.
SYSTEMATIC REVIEW PROTOCOL: PROSPERO (CRD420251000124).
METHODS: We conducted a PRISMA-guided systematic review and meta-analysis on PubMed, CENTRAL, EMBASE, and Web of Science from inception to June 2025. Randomised controlled trials of adults receiving CLV or manual vasopressor titration in perioperative and critical care settings were included. The primary outcome was time below target; secondary outcomes included time within and above target, time in hypotension (MAP <65 mmHg), vasopressor consumption, and length of stay.
RESULTS: Eight trials with 640 patients were analysed, including five trials conducted in the operating room and three trials in the ICU. Compared with manual titration, CLV significantly reduced time below target (mean difference [MD] = -15.81%; 95% CI = -20.38 to -11.25%; p < 0.001; n = 176), increased time in target (MD = 30.18%; 95% CI = 21.91 to 38.44%; p < 0.001; n = 216), reduced time in hypotension (SMD = -0.90; 95% CI = -1.64 to -0.17; p = 0.02; I2 = 79%), and hospital length of stay (MD = -1.12 days; 95% CI = -2.21 to -0.04 days; p = 0.04; I2 = 0%; n = 158). The length of post-anaesthesia care unit-intensive care unit stay (MD = -0.05 min, 95% CI = -1.10 to 1.00 min; p = 0.93; I2 = 0%; n = 198) did not differ between the two groups.
CONCLUSION: In surgical and critically-ill patients, closed-loop systems were associated with improved adherence to predefined blood pressure targets with reduced time below target and increased time in target compared to manual vasopressor titration. Whether these haemodynamic improvements translate into beneficial impact on patient outcomes will require confirmation in large multicentre randomised trials.
SYSTEMATIC REVIEW PROTOCOL: PROSPERO (CRD420251000124).