Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2007
UV-B irradiation attenuates dermal effects of botulinum toxin A: a randomized, double-blind, placebo-controlled study.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Sycha Thomas, Kotzailias Nicole, Kranz Gottfried, Trautinger Franz, Schnider Peter, Auff Eduard
Аннотация
BACKGROUND: Botulinum toxin type A (BoNT/A) is frequently used for cosmetic indications and hyperhidrosis.
OBJECTIVES: We investigated whether UV-B irradiation alleviates the BoNT/A effect on local sudomotor activity.
MATERIALS AND METHODS: In a randomized, double-blinded trial, the anhidrotic areas after BoNT/A (100 mU) injection 48 hours before and 14 days after UV-B irradiation were compared in six healthy volunteers.
RESULTS: UV-B irradiation alleviated BoNT/A effect by approximately 30% (p=.0017). The UV-B-evoked reduction of anhidrotic areas was constant over the observation period of 14 weeks.
CONCLUSIONS: When BoNT/A is applied intradermally, excessive exposure to UV-B and sunburn should be reconsidered. The authors have indicated no significant interest with commercial supporters.
OBJECTIVES: We investigated whether UV-B irradiation alleviates the BoNT/A effect on local sudomotor activity.
MATERIALS AND METHODS: In a randomized, double-blinded trial, the anhidrotic areas after BoNT/A (100 mU) injection 48 hours before and 14 days after UV-B irradiation were compared in six healthy volunteers.
RESULTS: UV-B irradiation alleviated BoNT/A effect by approximately 30% (p=.0017). The UV-B-evoked reduction of anhidrotic areas was constant over the observation period of 14 weeks.
CONCLUSIONS: When BoNT/A is applied intradermally, excessive exposure to UV-B and sunburn should be reconsidered. The authors have indicated no significant interest with commercial supporters.