Scandinavian journal of gastroenterology · 2025
Risk of biliary cancer in Finnish patients with choledochal malformations: A population-based register study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Raitio Arimatias, Hukkinen Maria, Hyvärinen Ilona, Nordin Arno, Gissler Mika, Pakarinen Mikko P
Аннотация
AIM: The purpose of this study was to assess the long-term risk of biliary cancer in patients diagnosed with choledochal malformations (CMs).
METHODS: The patient population was collected from the Helsinki University Hospital registers including all consecutive patients from 1987 to 2020. This data were complemented with the population-based register data from the Finnish Register of Congenital Malformations (FRM) and the Finnish Care Register for Health Care (1987-2020). Patient population was cross-linked with data from the Finnish Cancer Register data and the Cause-of-Death Register.
RESULTS: There were 209 patients with CM (142 females and 67 males). Most patients (n = 110, 53%) underwent biliary diversion surgery, 18 patients (8.6%) were treated endoscopically, and 57 patients (27%) were managed with observation only. Three patients (1.4%) were diagnosed with biliary cancer at a mean age of 60.3 years, and all of them died of their disease at a mean age of 65.4 years. Cholangitis was diagnosed in 33 patients (16%). Risk of inflammatory bowel diseases (IBDs) appeared higher in CM patients than in general Finnish population as IBD was diagnosed in 10 patients (4.8%) with relative risk (RR) of 4.9 (95% confidence interval [CI] 2.7-9.0).
CONCLUSIONS: CM seemed to be associated with an increased risk of biliary cancer although the prevalence was lower than in previous reports.
METHODS: The patient population was collected from the Helsinki University Hospital registers including all consecutive patients from 1987 to 2020. This data were complemented with the population-based register data from the Finnish Register of Congenital Malformations (FRM) and the Finnish Care Register for Health Care (1987-2020). Patient population was cross-linked with data from the Finnish Cancer Register data and the Cause-of-Death Register.
RESULTS: There were 209 patients with CM (142 females and 67 males). Most patients (n = 110, 53%) underwent biliary diversion surgery, 18 patients (8.6%) were treated endoscopically, and 57 patients (27%) were managed with observation only. Three patients (1.4%) were diagnosed with biliary cancer at a mean age of 60.3 years, and all of them died of their disease at a mean age of 65.4 years. Cholangitis was diagnosed in 33 patients (16%). Risk of inflammatory bowel diseases (IBDs) appeared higher in CM patients than in general Finnish population as IBD was diagnosed in 10 patients (4.8%) with relative risk (RR) of 4.9 (95% confidence interval [CI] 2.7-9.0).
CONCLUSIONS: CM seemed to be associated with an increased risk of biliary cancer although the prevalence was lower than in previous reports.