Liver international : official journal of the International Association for the Study of the Liver · 2025
Association of Primary Sclerosing Cholangitis With HLA-C*07:02 in a Japanese Population.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Okamoto Tatsuya, Okajima Hideaki, Kadohisa Masashi, Yamamoto Miki, Uebayashi Elena Yukie, Okumura Shinya, Sakamoto Katsunori, Ito Takashi, Hatano Etsuro
Аннотация
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a progressive, refractory liver disease often requiring liver transplantation (LT). The association between the disease onset and specific human leukocyte antigen (HLA) typing has been noted, but its relevance in the Japanese population is unknown.
METHODS: The HLA 5 locus (HLA-A, B, C, DRB1 and DQB1) 4-digit genotyping results of 31 patients with progressive PSC who underwent LT at our institution were compared to those of 873 healthy Japanese controls.
RESULTS: HLA-B*07:02 (p-corrected [pc] = 1.9 × 10-2), HLA-C*07:02 (pc = 3.9 × 10-5), HLA-DQB1*05:01 (pc = 3.7 × 10-2), and HLA-DRB1*01:01 (pc = 1.7 × 10-2) were identified as the susceptibility alleles for PSC. This correlation was stronger in patients with PSC complicated by ulcerative colitis than in those with PSC alone. Furthermore, analyses of the amino acid sequences of each HLA protein revealed that 15 amino acid residues of HLA-C were significantly associated with disease susceptibility (pc = 1.5 × 10-4-4.5 × 10-4).
CONCLUSIONS: HLA-C*07:02 is vulnerable to PSC aggravation in the Japanese population.
METHODS: The HLA 5 locus (HLA-A, B, C, DRB1 and DQB1) 4-digit genotyping results of 31 patients with progressive PSC who underwent LT at our institution were compared to those of 873 healthy Japanese controls.
RESULTS: HLA-B*07:02 (p-corrected [pc] = 1.9 × 10-2), HLA-C*07:02 (pc = 3.9 × 10-5), HLA-DQB1*05:01 (pc = 3.7 × 10-2), and HLA-DRB1*01:01 (pc = 1.7 × 10-2) were identified as the susceptibility alleles for PSC. This correlation was stronger in patients with PSC complicated by ulcerative colitis than in those with PSC alone. Furthermore, analyses of the amino acid sequences of each HLA protein revealed that 15 amino acid residues of HLA-C were significantly associated with disease susceptibility (pc = 1.5 × 10-4-4.5 × 10-4).
CONCLUSIONS: HLA-C*07:02 is vulnerable to PSC aggravation in the Japanese population.