International journal of clinical and experimental pathology · 2014
Unique expression pattern of viral proteins in human herpesvirus 8-positive plasmablastic lymphoma: a case report.
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Yamada Masatoshi, Katano Harutaka, Yotsumoto Mihoko, Hashimoto Hirotsugu, Muramatsu Takashi, Shiotsuka Mika, Fukutake Katsuyuki, Kuroda Masahiko
Аннотация
BACKGROUND: Human herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques.
CASE PRESENTATION: Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi's sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1.
CONCLUSION: These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.
CASE PRESENTATION: Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi's sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1.
CONCLUSION: These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.
Предметные рубрики MeSH
Antigens, ViralAutopsyBasic-Leucine Zipper Transcription FactorsBiomarkers, TumorCastleman DiseaseCell ProliferationFatal OutcomeHerpesvirus 8, HumanHost-Pathogen InteractionsHumansImmediate-Early ProteinsImmunohistochemistryLymphoma, AIDS-RelatedMaleMiddle AgedNuclear ProteinsRepressor ProteinsSarcoma, KaposiTrans-ActivatorsUreteral NeoplasmsViral ProteinsVirus Replication