Медицинская библиотека · Urology · 2000

Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis.

Yeniyol C O, Sorguc S, Minareci S, Ayder A R

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Аннотация

OBJECTIVES

To determine the effectiveness of intravenously administered interferon-alpha-2B for the prevention of testicular atrophy in postpubertal men with mumps orchitis.

METHODS

Eighteen patients with mumps orchitis were evaluated. The patients were hospitalized, and 3 x 1,000,000 IU intravenous interferon-alpha-2B was administered daily for a total of 7 days. All patients were evaluated by testicular biopsy on the 12th month after interferon treatment.

RESULTS

Biopsy results demonstrated total atrophy of the seminiferous tubules in seven (38.8%), 10% atrophy in three (16.6%), and no apparent histopathologic alterations except an arrest in spermatogenesis in eight (44.6%) testes.

CONCLUSIONS

Systematic treatment with interferon-alpha-2B does not seem completely effective in preventing testicular atrophy after mumps orchitis. Further investigations involving larger populations are needed.

Для цитирования: Yeniyol C O, Sorguc S, Minareci S, Ayder A R. Role of interferon-alpha-2B in prevention of testicular atrophy with unilateral mumps orchitis.. Urology. 2000. DOI: 10.1016/s0090-4295(00)00491-x.

Предметные рубрики MeSH

Adolescent Adult Antiviral Agents Atrophy Humans Interferon alpha-2 Interferon-alpha Male Mumps Orchitis Prospective Studies Recombinant Proteins Testis

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