Down-regulation of TP53 is a highlighted molecular event in gastric ulcer.

AIM: The current study explored the crucial dysregulate proteins and biochemical pathways in gastric ulcer as its main aim.

BACKGROUND

Gastric ulcer as an acid-related gastrointestinal disease is known as one of the most public gastrointestinal disorders.

METHODS

A total of 100 proteins from STRING database were analyzed by Cytoscape and its applications to find the central proteins and the related biochemical pathways. Action map analysis was applied to explore regulatory relationships between the critical proteins.

RESULTS

Network analysis and gene ontology revealed that IL6, ALB, TNF, INS, IL1B, IL10, TP53, CXCL8, and PTGS2 are the highlighted proteins related to gastric ulcer. Six clusters of biochemical pathways, namely "response to external stimulus," "multicellular organismal process," "regulation of biological quality," "cellular response to stimulus," "cellular response to chemical stimulus," and "transport" were identified as the dysregulated pathway in patients.

CONCLUSION

Down-regulation of TP53 by IL2, PTGS2, and TNF seems to be a main process occurring in gastric ulcer patients.