Journal of cosmetic dermatology · 2021
Serum level of serum amyloid A1 protein in patients with acne vulgaris.
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Akl Essam Mohamed, Halim Walid A Abdel
Аннотация
INTRODUCTION: The serum amyloid A1 (SAA1) protein is involved in many pathological diseases. The increased secretion of SAA1 can maintain inflammatory conditions. Acne vulgaris (AV) is a chronic inflammatory disease of pilosebaceous glands and may be associated with systemic manifestations.
AIM OF THE WORK: This study aimed to evaluate the serum level of SAA1 in patients with AV.
SUBJECTS AND METHODS: 120 participants were included in this study: 60 patients with AV and 60 apparently healthy volunteers as a control group. These participants were subjected to dermatological examination and assessments of lipid profile, fasting blood glucose (FBG), and serum SAA1.
RESULTS: Both serum SAA1 and FBG are significantly elevated in patients with AV than control (p < 0.0001 and p < 0.001, respectively). Furthermore, there are positive correlations between AV severity and SAA1 and FBG (p < 0.001 and p < 0.0001, respectively).
CONCLUSIONS: Serum amyloid A1 is increased in AV, and this elevation may play a role in the inflammatory milieu of AV.
AIM OF THE WORK: This study aimed to evaluate the serum level of SAA1 in patients with AV.
SUBJECTS AND METHODS: 120 participants were included in this study: 60 patients with AV and 60 apparently healthy volunteers as a control group. These participants were subjected to dermatological examination and assessments of lipid profile, fasting blood glucose (FBG), and serum SAA1.
RESULTS: Both serum SAA1 and FBG are significantly elevated in patients with AV than control (p < 0.0001 and p < 0.001, respectively). Furthermore, there are positive correlations between AV severity and SAA1 and FBG (p < 0.001 and p < 0.0001, respectively).
CONCLUSIONS: Serum amyloid A1 is increased in AV, and this elevation may play a role in the inflammatory milieu of AV.