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Nature communications · 2020

The genetic architecture of human brainstem structures and their involvement in common brain disorders.

СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Elvsåshagen Torbjørn, Bahrami Shahram, van der Meer Dennis, Agartz Ingrid, Alnæs Dag, Barch Deanna M, Baur-Streubel Ramona, Bertolino Alessandro, Beyer Mona K, Blasi Giuseppe, Borgwardt Stefan, Boye Birgitte, Buitelaar Jan, Bøen Erlend, Celius Elisabeth Gulowsen, Cervenka Simon, Conzelmann Annette, Coynel David, Di Carlo Pasquale, Djurovic Srdjan, Eisenacher Sarah, Espeseth Thomas, Fatouros-Bergman Helena, Flyckt Lena, Franke Barbara, Frei Oleksandr, Gelao Barbara, Harbo Hanne Flinstad, Hartman Catharina A, Håberg Asta, Heslenfeld Dirk, Hoekstra Pieter J, Høgestøl Einar A, Jonassen Rune, Jönsson Erik G, Karolinska Schizophrenia Project (KaSP) consortium, Kirsch Peter, Kłoszewska Iwona, Lagerberg Trine Vik, Landrø Nils Inge, Le Hellard Stephanie, Lesch Klaus-Peter, Maglanoc Luigi A, Malt Ulrik F, Mecocci Patrizia, Melle Ingrid, Meyer-Lindenberg Andreas, Moberget Torgeir, Nordvik Jan Egil, Nyberg Lars, Connell Kevin S O', Oosterlaan Jaap, Papalino Marco, Papassotiropoulos Andreas, Pauli Paul, Pergola Giulio, Persson Karin, de Quervain Dominique, Reif Andreas, Rokicki Jaroslav, van Rooij Daan, Shadrin Alexey A, Schmidt André, Schwarz Emanuel, Selbæk Geir, Soininen Hilkka, Sowa Piotr, Steen Vidar M, Tsolaki Magda, Vellas Bruno, Wang Lei, Westman Eric, Ziegler Georg C, Zink Mathias, Andreassen Ole A, Westlye Lars T, Kaufmann Tobias

Аннотация

Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты