[Consensus on diagnosis, treatment and clinical research of meningeal metastasis (2026 edition)].

Meningeal metastasis is one of the serious complications of advanced malignant tumors, characterized by high malignancy and poor prognosis. Beijing Association of Oncology Clinical Research Committee and China Hospital Association Cancer Hospital Branch organized multidisciplinary experts to summarize the latest diagnostic criteria and therapeutic advances for meningeal metastasis, covering traditional therapies such as surgical intervention, radiotherapy, systemic chemotherapy, and intrathecal chemotherapy. It also emphasizes the potential of emerging strategies, including targeted therapy and immunotherapy, in the treatment of meningeal metastasis. Furthermore, this consensus focuses on the key elements of clinical research design for meningeal metastasis, highlighting the necessity of standardizing treatment response assessment and clinical trial endpoints. To optimize the design of clinical studies for meningeal metastasis, this consensus recommends the adoption of randomized and blinded designs, combined with biomarker analysis and the use of appropriate statistical tools. These measures are aimed at enhancing the quality and efficiency of clinical trials, thereby providing more evidence-based medical support for the treatment of meningeal metastasis.