Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
Peroxiredoxin-2 represses NRAS-mutated melanoma cells invasion by modulating EMT markers.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Noma Isabella Harumi Yonehara, Carvalho Larissa Anastacio da Costa, Camarena Denisse Esther Mallaupoma, Silva Renaira Oliveira, Moraes Junior Manoel Oliveira de, de Souza Sophia Tavares, Newton-Bishop Julia, Nsengimana Jérémie, Maria-Engler Silvya Stuchi
Аннотация
The second most common mutation in melanoma occurs in NRAS oncogene, being a more aggressive disease that has no effective approved treatment. Besides, cellular plasticity limits better outcomes of the advanced and therapy-resistant patients. Peroxiredoxins (PRDXs) control cellular processes through direct hydrogen peroxide oxidation or by redox-relaying processes. Here, we demonstrated that PRDX2 could act as a modulator of multiple EMT markers in NRAS-mutated melanomas. PRDX2 knockdown lead to phenotypic changes towards invasion in human reconstructed skin and the treatment with a PRDX mimetic (gliotoxin), decreased migration in PRDX2-deficient cells. We also confirmed the favorable clinical outcome of patients expressing PRDX2 in a large primary melanoma cohort. This study contributes to our knowledge about genes involved in phenotype switching and opens a new perspective for PRDX2 as a biomarker and target in NRAS-mutated melanomas.