Journal of affective disorders · 2018
The regional homogeneity of cingulate-precuneus regions: The putative biomarker for depression and anxiety.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Lai Chien-Han
Аннотация
OBJECTIVES: In addition to clinical interview, the modern putative biomarker to differentiate depression and anxiety would be warranted. The translational medicine characteristics of neuroimaging, such as the regional homogeneity (ReHo), is an option for depression and anxiety. Therefore we designed this study trying to identify the biomarker pattern for depression and anxiety.
METHODS: Resting-state functional magnetic resonance imaging was acquired for 53 patients with first-episode medicine-naïve major depressive disorder (MDD), 53 first-episode medicine-naïve patients with panic disorder (PD) and 54 controls. The calculation of ReHo was performed. The ANOVA repeated measures were applied for the 3 groups to investigate the putative differences between MDD and PD (FDR corrected p < 0.05).
RESULTS: After multiple comparisons, the major findings of ReHo were found in the bilateral anterior cingulate cortex and bilateral precuneus. MDD group had lower ReHo values than PD group in the left anterior cingulate cortex. MDD group had significant alterations of ReHo in the left anterior cingulate cortex and bilateral precuneus when compared to controls. PD group had alterations in the bilateral precuneus when compared to controls.
CONCLUSION: The specific cingulate alterations might be a putative ReHo biomarker to differentiate MDD from PD in cingulate-precuneus background for ReHo alterations.
METHODS: Resting-state functional magnetic resonance imaging was acquired for 53 patients with first-episode medicine-naïve major depressive disorder (MDD), 53 first-episode medicine-naïve patients with panic disorder (PD) and 54 controls. The calculation of ReHo was performed. The ANOVA repeated measures were applied for the 3 groups to investigate the putative differences between MDD and PD (FDR corrected p < 0.05).
RESULTS: After multiple comparisons, the major findings of ReHo were found in the bilateral anterior cingulate cortex and bilateral precuneus. MDD group had lower ReHo values than PD group in the left anterior cingulate cortex. MDD group had significant alterations of ReHo in the left anterior cingulate cortex and bilateral precuneus when compared to controls. PD group had alterations in the bilateral precuneus when compared to controls.
CONCLUSION: The specific cingulate alterations might be a putative ReHo biomarker to differentiate MDD from PD in cingulate-precuneus background for ReHo alterations.