Journal of dentistry · 2026
Applications of graphene-based quantum dots in oral healthcare: A scoping review of current evidence and future perspectives.
СтатьяScoping ReviewНазвание и аннотация: Перевод пока не подготовлен
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Huang Mengyu, Dissanayaka Waruna Lakmal, Yiu Cynthia
Аннотация
OBJECTIVES: This review aims to provide a comprehensive overview of graphene-based quantum dots (GBQDs) in oral healthcare, focusing on their physicochemical properties tailored to the oral microenvironment, their applications in dental disease management, current research limitations, and future perspectives for clinical translation.
DATA SOURCES: systematic literature search was conducted in PubMed, Web of Science, and Scopus for publications from the last 15 years up to February 2026. Keywords included "graphene quantum dots", "graphene oxide quantum dots", "dentistry", "oral", "antibacterial", "tissue regeneration", "oral cancer", and "dental materials". Manual searching of reference lists was also performed.
STUDY SELECTION: From 401 initially identified records, 49 studies underwent full-text review, and 20 representative studies were included based on their relevance to the oral microenvironment and scientific contribution to the field. Studies were categorized into four key areas: antibacterial applications, tissue regeneration, oral cancer therapy, and dental material modification.
CONCLUSIONS: GBQDs exhibit unique properties such as nanoscale dimensions, tunable fluorescence, high surface area for drug loading, and multimodal antibacterial mechanisms, which make them particularly suitable for the complex oral environment. Current applications span infectious disease management, tissue regeneration, oral cancer theranostics, and dental material enhancement. However, challenges remain in expanding applications beyond current focus, understanding microbial interactions, and achieving vascular and neural regeneration. Future efforts should prioritize disease-specific design, multi-species inhibition strategies, and clinical translation.
CLINICAL SIGNIFICANCE: This scoping review provides clinicians and researchers with a comprehensive understanding of GBQDs' potential in dentistry, highlighting the role in targeted drug delivery, antimicrobial therapy, tissue engineering, and diagnostic imaging, thereby informing future clinical applications and research directions in nanodentistry.
DATA SOURCES: systematic literature search was conducted in PubMed, Web of Science, and Scopus for publications from the last 15 years up to February 2026. Keywords included "graphene quantum dots", "graphene oxide quantum dots", "dentistry", "oral", "antibacterial", "tissue regeneration", "oral cancer", and "dental materials". Manual searching of reference lists was also performed.
STUDY SELECTION: From 401 initially identified records, 49 studies underwent full-text review, and 20 representative studies were included based on their relevance to the oral microenvironment and scientific contribution to the field. Studies were categorized into four key areas: antibacterial applications, tissue regeneration, oral cancer therapy, and dental material modification.
CONCLUSIONS: GBQDs exhibit unique properties such as nanoscale dimensions, tunable fluorescence, high surface area for drug loading, and multimodal antibacterial mechanisms, which make them particularly suitable for the complex oral environment. Current applications span infectious disease management, tissue regeneration, oral cancer theranostics, and dental material enhancement. However, challenges remain in expanding applications beyond current focus, understanding microbial interactions, and achieving vascular and neural regeneration. Future efforts should prioritize disease-specific design, multi-species inhibition strategies, and clinical translation.
CLINICAL SIGNIFICANCE: This scoping review provides clinicians and researchers with a comprehensive understanding of GBQDs' potential in dentistry, highlighting the role in targeted drug delivery, antimicrobial therapy, tissue engineering, and diagnostic imaging, thereby informing future clinical applications and research directions in nanodentistry.