Gynecologic oncology reports · 2026
The impact on sexual wellbeing after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer treatment.
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Falla-Zuniga Luis Felipe, Sardi Armando, King Mary Caitlin, Pawlikowski Kathleen, Kovalik Vladislav, Iugai Sergei, Nieroda Carol, Gushchin Vadim, Diaz-Montes Teresa
Аннотация
BACKGROUND: Adding hyperthermic intraperitoneal chemotherapy (HIPEC) to extensive cytoreductive surgery (CRS) for advanced ovarian cancer (OC) raises concerns about sexual morbidity, yet, sexual wellbeing is largely overlooked in CRS/HIPEC trials and practice. We evaluated the sexual wellbeing of OC survivors after CRS/HIPEC.
METHODS: This single center cross-sectional study surveyed FIGO stage III-IV OC patients who underwent primary CRS/HIPEC ≥ 3 months prior using an anonymous survey and the EORTC QLQ-SHQ22 questionnaire. Sexual satisfaction and pain scales were linearly transformed (0-100), with higher scores indicating higher satisfaction and more pain. Qualitative themes were identified from a single open-ended survey question.
RESULTS: Overall, 33/68 (48.5%) patients completed questionnaires. Most were aged 61-80 years (66.7%), heterosexual (97.0%), had CRS/HIPEC > 1 year prior (81.8%), and reported an active sex life as "not at all" / "a little" important (72.7%). Mean sexual satisfaction score was 31 ± 26. A negative change in their sexual wellbeing was reported by 13/14 (92.8%), which was associated with lower sexual satisfaction (p = 0.024). Greater sexual satisfaction was associated with regular exercise (p = 0.025), absence of comorbidities (p = 0.041), and sexual health support from providers (p = 0.019). All patients reported sexual morbidity; vaginal dryness/hot flashes (14/33, 42.4%) were most common. Only 33% (11/33) of patients received sexual wellbeing-related healthcare support, of whom 72.7% found it useful. Of 3 identified themes, "Other Priorities" was the most common.
CONCLUSIONS: Changes in sexual wellbeing after CRS/HIPEC were common, but healthcare support was limited. Those receiving support reported higher sexual satisfaction. Sexual wellbeing was reframed within broader survivorship priorities.
METHODS: This single center cross-sectional study surveyed FIGO stage III-IV OC patients who underwent primary CRS/HIPEC ≥ 3 months prior using an anonymous survey and the EORTC QLQ-SHQ22 questionnaire. Sexual satisfaction and pain scales were linearly transformed (0-100), with higher scores indicating higher satisfaction and more pain. Qualitative themes were identified from a single open-ended survey question.
RESULTS: Overall, 33/68 (48.5%) patients completed questionnaires. Most were aged 61-80 years (66.7%), heterosexual (97.0%), had CRS/HIPEC > 1 year prior (81.8%), and reported an active sex life as "not at all" / "a little" important (72.7%). Mean sexual satisfaction score was 31 ± 26. A negative change in their sexual wellbeing was reported by 13/14 (92.8%), which was associated with lower sexual satisfaction (p = 0.024). Greater sexual satisfaction was associated with regular exercise (p = 0.025), absence of comorbidities (p = 0.041), and sexual health support from providers (p = 0.019). All patients reported sexual morbidity; vaginal dryness/hot flashes (14/33, 42.4%) were most common. Only 33% (11/33) of patients received sexual wellbeing-related healthcare support, of whom 72.7% found it useful. Of 3 identified themes, "Other Priorities" was the most common.
CONCLUSIONS: Changes in sexual wellbeing after CRS/HIPEC were common, but healthcare support was limited. Those receiving support reported higher sexual satisfaction. Sexual wellbeing was reframed within broader survivorship priorities.