Gan to kagaku ryoho. Cancer & chemotherapy · 2014
[Four cases of bevacizumab-related gastrointestinal perforation].
Клинический случайАннотация на английскомСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Uchino Tairin, Mishima Hideyuki, Kimura Kengo, Mori Daiki, Ando Keiichi, Nagata Hiroshi, Kondo Riki, Kosaka Kenshi, Ohashi Norifumi, Ito Nobuhiro, Arikawa Takashi, Miyachi Masahiko, Suzumura Kazuyoshi, Sano Tsuyoshi, Nonami Toshiaki
Аннотация
We report 4 cases of gastrointestinal perforation associated with systemic administration of bevacizumab. Case 1: A 51- year-old man with colorectal cancer (CRC) received mFOLFOX+bevacizumab (Bev). A small intestinal perforation occurred 7 days after Bev administration (Bev-a) and was successfully treated with omental packing. Case 2: A 50-year-old woman with CRC received capecitabine+Bev. A small intestinal perforation was detected 5 days after Bev-a, and was successfully treated with primary suture and an omental flap. Case 3: A 74-year-old man with CRC received CapeOX+Bev. A duodenal perforation occurred on the same day as Bev-a, but could be treated conservatively. Case 4: A 57-year-old man with lung cancer received DTX+Bev. A small intestinal perforation occurred 13 days after Bev-a, but this could be managed with primary suture and an omental flap. The gastrointestinal perforation presented with mild abdominal pain and was detected within 14 days after Bev-a in each of these 4 cases. Three patients were successfully treated with only minimal surgical procedures and 1 patient could be managed with conservative treatment for a perforated duodenal ulcer.