Sleep · 2015
Experimental Sleep Restriction Facilitates Pain and Electrically Induced Cortical Responses.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Matre Dagfinn, Hu Li, Viken Leif A, Hjelle Ingri B, Wigemyr Monica, Knardahl Stein, Sand Trond, Nilsen Kristian Bernhard
Аннотация
STUDY OBJECTIVES: Sleep restriction (SR) has been hypothesized to sensitize the pain system. The current study determined whether experimental sleep restriction had an effect on experimentally induced pain and pain-elicited electroencephalographic (EEG) responses.
DESIGN: A paired crossover study.
INTERVENTION: Pain testing was performed after 2 nights of 50% SR and after 2 nights with habitual sleep (HS).
SETTING: Laboratory experiment at research center.
PARTICIPANTS: Self-reported healthy volunteers (n = 21, age range: 18-31 y).
MEASUREMENTS AND RESULTS: Brief high-density electrical stimuli to the forearm skin produced pinprick-like pain. Subjective pain ratings increased after SR, but only in response to the highest stimulus intensity (P = 0.018). SR increased the magnitude of the pain-elicited EEG response analyzed in the time-frequency domain (P = 0.021). Habituation across blocks did not differ between HS and SR. Event-related desynchronization (ERD) was reduced after SR (P = 0.039). Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017).
CONCLUSION: Sleep restriction (SR) increased the sensitivity to pressure pain and to electrically induced pain of moderate, but not low, intensity. The increased electrical pain could not be explained by a difference in habituation. Increased response magnitude is possibly related to reduced processing within the somatosensory cortex after partial SR.
DESIGN: A paired crossover study.
INTERVENTION: Pain testing was performed after 2 nights of 50% SR and after 2 nights with habitual sleep (HS).
SETTING: Laboratory experiment at research center.
PARTICIPANTS: Self-reported healthy volunteers (n = 21, age range: 18-31 y).
MEASUREMENTS AND RESULTS: Brief high-density electrical stimuli to the forearm skin produced pinprick-like pain. Subjective pain ratings increased after SR, but only in response to the highest stimulus intensity (P = 0.018). SR increased the magnitude of the pain-elicited EEG response analyzed in the time-frequency domain (P = 0.021). Habituation across blocks did not differ between HS and SR. Event-related desynchronization (ERD) was reduced after SR (P = 0.039). Pressure pain threshold of the trapezius muscle region also decreased after SR (P = 0.017).
CONCLUSION: Sleep restriction (SR) increased the sensitivity to pressure pain and to electrically induced pain of moderate, but not low, intensity. The increased electrical pain could not be explained by a difference in habituation. Increased response magnitude is possibly related to reduced processing within the somatosensory cortex after partial SR.